Comparison the efficacy of Hypericum perforatum and vitex agnus-castus in hot flushes: A double-blinded randomized controlled trial
DOI:
https://doi.org/10.22122/cdj.v1i2.53Keywords:
Hypericum, Menopause, Plants, Randomized Controlled Trial, Vitex Agnus-Castus, Herbal DrugAbstract
BACKGROUND: Treating hot flushes in middle-aged women is an important health issue. Recently, Hypericum perforatum and vitex agnus-castus were investigated to decrease hot flushes. This study was conducted to compare the efficacy of Hypericum perforatum and vitex agnus-castus in hot flushes among menopausal women.
METHODS: This was a randomized, double-blinded, controlled trial. The Hypericum perforatum group received 330 µg Hypericum perforatum and second group received vitex agnus-castus in the same tablet forms. Data were analyzed using repeated measurement for comparing Greene Climacteric Scale.
RESULTS: Trend of Greene Climacteric Scale and hot flushness attack were decreased in both groups and it presented a decreasing trend within two months; however, no statistically significant difference was observed between the two groups.
CONCLUSION: It seems that Hypericum perforatum and vitex agnus-castus could be similarly effective in decreasing hot flushes. These two medicines did not have any special severe side effects.
References
Ortmann O, Lattrich C. The treatment of climacteric symptoms. Dtsch Arztebl Int 2012; 109(17): 316-23.
Barnabei VM, Cochrane BB, Aragaki AK, Nygaard I, Williams RS, McGovern PG, et al. Menopausal symptoms and treatment-related effects of estrogen and progestin in the Women's Health Initiative. Obstet Gynecol 2005; 105(5 Pt 1): 1063-73.
Azizi H, Feng LY, Du L, Hua WC, Bahrami-Taghanaki H, Ollah EH, et al. Menopause-related symptoms: traditional Chinese medicine vs hormone therapy. Altern Ther Health Med 2011; 17(4): 48-53.
National Institutes of Health. Facts about Menopausal Hormone Therapy [Online]. [cited 2005]; Available from: URL: http://www.nhlbi.nih.gov/health/women/pht_facts.htm/
Canning S, Waterman M, Orsi N, Ayres J, Simpson N, Dye L. The efficacy of Hypericum perforatum (St John's wort) for the treatment of premenstrual syndrome: a randomized, double-blind, placebo-controlled trial. CNS Drugs 2010; 24(3): 207-25.
Uebelhack R, Blohmer JU, Graubaum HJ, Busch R, Gruenwald J, Wernecke KD. Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Obstet Gynecol 2006; 107(2 Pt 1): 247-55.
Van Die MD, Burger HG, Teede HJ, Bone KM. Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaints. J Altern Complement Med 2009; 15(8): 853-62.
Nelson HD, Vesco KK, Haney E, Fu R, Nedrow A, Miller J, et al. Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. JAMA 2006; 295(17): 2057-71.
Abdali K, Khajehei M, Tabatabaee HR. Effect of St John's wort on severity, frequency, and duration of hot flashes in premenopausal, perimenopausal and postmenopausal women: a randomized, double-blind, placebo-controlled study. Menopause 2010; 17(2): 326-31.
Al-Akoum M, Maunsell E, Verreault R, Provencher L, Otis H, Dodin S. Effects of Hypericum perforatum (St. John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. Menopause 2009; 16(2): 307-14.
Muller WE. Current St John's wort research from mode of action to clinical efficacy. Pharmacol Res 2003; 47(2): 101-9.
Abbaspour Z, Hajikhani N, Afshari P. Effect of vitex agnus castuson early menopausal symptoms in postmenopausal women. J Sabzevar Univ Med Sci 2005; 12(2): 26-30. [In Persian].
Kazemian A, Bromand K, Ghanadi A, Nooryan K. Effect of Vitagnus and Passi-pay on hot flash of menopausal women. J Shahrekord Univ Med Sci 2005; 7(1): 39-45. [In Persian].
Christie VM. A dialogue between practitioners of alternative (traditional) medicine and modern (western) medicine in Norway. Soc Sci Med 1991; 32(5): 549-52.
Chattha R, Kulkarni R, Nagarathna R, Nagendra HR. Factor analysis of Greene's Climacteric Scale for Indian women. Maturitas 2008; 59(1): 22-7.
Greene JG. Constructing a standard climacteric scale. Maturitas 1998; 29(1): 25-31.
Grube B, Walper A, Wheatley D. St. John's Wort extract: efficacy for menopausal symptoms of psychological origin. Adv Ther 1999; 16(4): 177-86.
Rotem C, Kaplan B. Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot study. Gynecol Endocrinol 2007; 23(2): 117-22.
Chopin LB. Vitex agnus castus essential oil and menopausal balance: a research update [Complementary Therapies in Nursing and Midwifery 8 (2003) 148-154]. Complement Ther Nurs Midwifery 2003; 9(3): 157-60.