Comparison the efficacy of Hypericum perforatum and vitex agnus-castus in hot flushes: A double-blinded randomized controlled trial

Masumeh Ghazanfarpour, Ebrahim Ghaderi, Masumeh Kaviani, Kazhal Haddadian

DOI: 10.22122/cdj.v1i2.53

Abstract


BACKGROUND: Treating hot flushes in middle-aged women is an important health issue. Recently, Hypericum perforatum and vitex agnus-castus were investigated to decrease hot flushes. This study was conducted to compare the efficacy of Hypericum perforatum and vitex agnus-castus in hot flushes among menopausal women.

METHODS: This was a randomized, double-blinded, controlled trial. The Hypericum perforatum group received 330 µg Hypericum perforatum and second group received vitex agnus-castus in the same tablet forms. Data were analyzed using repeated measurement for comparing Greene Climacteric Scale.

RESULTS: Trend of Greene Climacteric Scale and hot flushness attack were decreased in both groups and it presented a decreasing trend within two months; however, no statistically significant difference was observed between the two groups.

CONCLUSION: It seems that Hypericum perforatum and vitex agnus-castus could be similarly effective in decreasing hot flushes. These two medicines did not have any special severe side effects.

 


Keywords


Hypericum, Menopause, Plants, Randomized Controlled Trial, Vitex Agnus-Castus, Herbal Drug

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References


Ortmann O, Lattrich C. The treatment of climacteric symptoms. Dtsch Arztebl Int 2012; 109(17): 316-23.

Barnabei VM, Cochrane BB, Aragaki AK, Nygaard I, Williams RS, McGovern PG, et al. Menopausal symptoms and treatment-related effects of estrogen and progestin in the Women's Health Initiative. Obstet Gynecol 2005; 105(5 Pt 1): 1063-73.

Azizi H, Feng LY, Du L, Hua WC, Bahrami-Taghanaki H, Ollah EH, et al. Menopause-related symptoms: traditional Chinese medicine vs hormone therapy. Altern Ther Health Med 2011; 17(4): 48-53.

National Institutes of Health. Facts about Menopausal Hormone Therapy [Online]. [cited 2005]; Available from: URL: http://www.nhlbi.nih.gov/health/women/pht_facts.htm/

Canning S, Waterman M, Orsi N, Ayres J, Simpson N, Dye L. The efficacy of Hypericum perforatum (St John's wort) for the treatment of premenstrual syndrome: a randomized, double-blind, placebo-controlled trial. CNS Drugs 2010; 24(3): 207-25.

Uebelhack R, Blohmer JU, Graubaum HJ, Busch R, Gruenwald J, Wernecke KD. Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Obstet Gynecol 2006; 107(2 Pt 1): 247-55.

Van Die MD, Burger HG, Teede HJ, Bone KM. Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaints. J Altern Complement Med 2009; 15(8): 853-62.

Nelson HD, Vesco KK, Haney E, Fu R, Nedrow A, Miller J, et al. Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. JAMA 2006; 295(17): 2057-71.

Abdali K, Khajehei M, Tabatabaee HR. Effect of St John's wort on severity, frequency, and duration of hot flashes in premenopausal, perimenopausal and postmenopausal women: a randomized, double-blind, placebo-controlled study. Menopause 2010; 17(2): 326-31.

Al-Akoum M, Maunsell E, Verreault R, Provencher L, Otis H, Dodin S. Effects of Hypericum perforatum (St. John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. Menopause 2009; 16(2): 307-14.

Muller WE. Current St John's wort research from mode of action to clinical efficacy. Pharmacol Res 2003; 47(2): 101-9.

Abbaspour Z, Hajikhani N, Afshari P. Effect of vitex agnus castuson early menopausal symptoms in postmenopausal women. J Sabzevar Univ Med Sci 2005; 12(2): 26-30. [In Persian].

Kazemian A, Bromand K, Ghanadi A, Nooryan K. Effect of Vitagnus and Passi-pay on hot flash of menopausal women. J Shahrekord Univ Med Sci 2005; 7(1): 39-45. [In Persian].

Christie VM. A dialogue between practitioners of alternative (traditional) medicine and modern (western) medicine in Norway. Soc Sci Med 1991; 32(5): 549-52.

Chattha R, Kulkarni R, Nagarathna R, Nagendra HR. Factor analysis of Greene's Climacteric Scale for Indian women. Maturitas 2008; 59(1): 22-7.

Greene JG. Constructing a standard climacteric scale. Maturitas 1998; 29(1): 25-31.

Grube B, Walper A, Wheatley D. St. John's Wort extract: efficacy for menopausal symptoms of psychological origin. Adv Ther 1999; 16(4): 177-86.

Rotem C, Kaplan B. Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot study. Gynecol Endocrinol 2007; 23(2): 117-22.

Chopin LB. Vitex agnus castus essential oil and menopausal balance: a research update [Complementary Therapies in Nursing and Midwifery 8 (2003) 148-154]. Complement Ther Nurs Midwifery 2003; 9(3): 157-60.


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