Effectiveness of topical Clinda Soap in the treatment of acne vulgaris

Farokh Rad, Mansoor Mirbagheri, Mohammad Hossein Pakdaman, Roxana Yaghmaee, Fardin Gharibi

DOI: 10.22122/cdj.v1i1.17


BACKGROUND: A variety of drugs can be used for the treatment of acne vulgaris. Every medicine acts against one or some of the mechanisms of the pathogenesis of acne vulgaris. This study was conducted to assess the therapeutic effect of Clinda Soap in the treatment of acne vulgaris.

METHODS: This randomized, double-blind, clinical trial included 82 patients (age: 15-35 years) with mild to moderate acne vulgaris. The study protocol was approved by the ethics committee of Kurdistan University of Medical Sciences (Sanandaj, Iran). The patients were randomized into two groups to receive the standard treatment for acne vulgaris with either Clinda Soap (containing clindamycin hydrochloride 1%, manufactured by Shadakish Company, Iran) or a placebo soap. Both the intervention and control groups were asked to apply soaps twice daily for three months. Monthly examinations were performed by a dermatologist to ensure proper use of the soaps and to assess the rate of recovery and possible complications. Data was analyzed using repeated measures analysis of variance in SPSS.

RESULTS: The mean age of patients was 21.1 ± 4.7 years in the intervention group and 21.5 ± 4.8 years in the control group. The mean duration of the disease was 3.0 ± 1.5 and 3.1 ± 1.8 months in the intervention and control groups, respectively. The mean number of comedones in the two groups had no significant difference at any monthly visit. In contrast, at all visits, significantly fewer papules and pustules were observed in the intervention group than in the control. Significant intra-group and inter-group differences in the number of inflammatory lesions (papules and pustules) were also seen.

CONCLUSION: In general, it can be concluded that Clinda Soap is effective in the treatment of acne vulgaris. The recovery rate of papules and pustules was higher than that of comedones. Easy application of this soap together with its low cost and few adverse effects will increase patients' compliance.


Acne Vulgaris, Clinda Soap, Treatment

Full Text:



Habif TP. Clinical dermatology: a color guide to diagnosis and therapy. 4th ed. Philadelphia, PA: Mosby; 2004.

Bach M, Bach D. Psychiatric and psychometric issues in acne excoriee. Psychother Psychosom 1993; 60(3-4): 207-10.

Simpson NB. Acne. In: Williams HC, Strachan CP, Editors. The challenge of dermato-epidemiology. Boca Raton, FL: CRC Press; 1997.

Goulden V. Guidelines for the management of acne vulgaris in adolescents. Paediatr Drugs 2003; 5(5): 301-13.

Stern RS. Acne therapy. Medication use and sources of care in office-based practice. Arch Dermatol 1996; 132(7): 776-80.

Diane M, Thioboutot J, Straus S. Disease of the sebaceous gland. In: Fitzpatrick TB, Freedberg IM, Editors. Fitzpatrick&s dermatology in general medicine. 6th ed. New York, NY: McGraw-Hill; 2003. p. 672-84.

Eady EA. Bacterial resistance in acne. Dermatology 1998; 196(1): 59-66.

Layton AM. A review on the treatment of acne vulgaris. Int J Clin Pract 2006; 60(1): 64-72.

Enshaieh S, Jooya A, Siadat AH, Iraji F. The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study. Indian J Dermatol Venereol Leprol 2007; 73(1): 22-5.

Shalita AR, Smith JG, Parish LC, Sofman MS, Chalker DK. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. Int J Dermatol 1995; 34(6): 434-7.

Munro-Ashman D. Acne vulgaris in a public school. Trans St Johns Hosp Dermatol Soc 1963; 49: 144-8.

Burton JL, Cunliffe WJ, Stafford I, Shuster S. The prevalence of acne vulgaris in adolescence. Br J Dermatol 1971; 85(2): 119-26.

Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol 1997; 36(6): 416-8.

Del Rosso JQ, Schmidt NF. A review of the anti-inflammatory properties of clindamycin in the treatment of acne vulgaris. Cutis 2010; 85(1): 15-24.

Cunliffe WJ, Fernandez C, Bojar R, Kanis R, West F. An observer-blind parallel-group, randomized, multicentre clinical and microbiological study of a topical clindamycin/zinc gel and a topical clindamycin lotion in patients with mild/moderate acne. J Dermatolog Treat 2005; 16(4): 213-8.

Zouboulis CC, Derumeaux L, Decroix J, Maciejewska-Udziela B, Cambazard F, Stuhlert A. A multicentre, single-blind, randomized comparison of a fixed clindamycin phosphate/tretinoin gel formulation (Velac) applied once daily and a clindamycin lotion formulation (Dalacin T) applied twice daily in the topical treatment of acne vulgaris. Br J Dermatol 2000; 143(3): 498-505.

NilFroushzadeh MA, Siadat AH, Baradaran EH, Moradi S. Clindamycin lotion alone versus combination lotion of clindamycin phosphate plus tretinoin versus combination lotion of clindamycin phosphate plus salicylic acid in the topical treatment of mild to moderate acne vulgaris: a randomized control trial. Indian J Dermatol Venereol Leprol 2009; 75(3): 279-82.

Pazoki-Toroudi H, Nilforoushzadeh MA, Ajami M, Jaffary F, Aboutaleb N, Nassiri-Kashani M, et al. Combination of azelaic acid 5% and clindamycin 2% for the treatment of acne vulgaris. Cutan Ocul Toxicol 2011; 30(4): 286-91.

Draelos ZD, Potts A, Alio Saenz AB. Randomized tolerability analysis of clindamycin phosphate 1.2%-tretinoin 0.025% gel used with benzoyl peroxide wash 4% for acne vulgaris. Cutis 2010; 86(6): 310-8.


  • There are currently no refbacks.

Creative Commons Attribution-NonCommercial 4.0

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.