The effects of mindfulness-based stress reduction therapy on psychopathology symptoms and stress response in patients with multiple sclerosis: Short communication

Mindfulness-based stress reduction treatment on psychopathology symptoms

Authors

Keywords:

Mindfulness, Psychopathology, Stress Response, Multiple Sclerosis

Abstract

BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory condition that affects the central nervous system (CNS). The purpose of this study was to examine how a mindfulness-based stress reduction (MBSR) intervention impacted psychopathology symptoms and stress responses in patients with MS.

METHODS: In the second half of 2018-2019, a quasi-experimental study was carried out with a pretest-posttest control design, followed by a one-month monitoring period in Kerman City, Iran. Through purposeful sampling, 30 patients were selected and then randomly divided into experimental and control groups, with 15 individuals in each group. The experimental group underwent MBSR therapy sessions, structured individually, spanning eight 90-minute sessions, and held weekly, following Kabat-Zinn's MBSR program. Data collection for the study was done using the Stress Response Inventory (SRI) and the Symptom Checklist-90-Revised (SCL-90-R). The collected data were analyzed using repeated measures analysis of variance (ANOVA) through SPSS.

RESULTS: Mindfulness Based Stress Reduction (MESR) did not significantly impact psychosis and paranoia symptoms (P < 0.05). The therapy also helped with stress response in these patients (P < 0.05). This effect lasted through the follow-up phase.

CONCLUSION: The study showed that MBSR therapy helped reduce psychiatric symptoms like anxiety and depression in patients with MS.

References

Ghasemi N, Razavi S, Nikzad E. Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy. Cell J. 2017; 19(1): 1-10.

Homayuni A, Hosseini Z, Abedini S. Explaining stress coping behaviors in patients with multiple sclerosis based on the PRECEDE model: a qualitative directed content analysis. BMC Psychiatry. 2021; 21(1): 631.

Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, et al. Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition. Mult Scler. 2020; 26(14): 1816-21.

Dehghani A, Khoramkish M, Shahsavari Isfahani S. Challenges in the Daily Living Activities of Patients with Multiple Sclerosis: A Qualitative Content Analysis. Int J Community Based Nurs Midwifery. 2019; 7(3): 201-10.

Shariff EM, Al-Shammrani FJ, Nazish S, Zafar AS, Shahid RM, Khuda IE, et al. Is non-traditional therapy for multiple sclerosis overwhelming in Saudi Arabia. Neurosciences (Riyadh). 2019; 24(3): 192-8.

Kabat-Zinn J. Mindfulness-based stress reduction (MBSR). Constr Hum Sci. 2003; 8(2): 73-83.

Kabat-Zinn J. An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. Gen Hosp Psychiatry. 1982; 4(1): 33-47.

Lindsay EK, Creswell JD. Mechanisms of mindfulness training: Monitor and Acceptance Theory (MAT). Clin Psychol Rev. 2017; 51: 48-59.

Sayyah M, Bagheri P, Karimi N, Ghasemzadeh A. The Effectiveness of Group Cognitive Behavioral Therapy in Treating Obsessive-Compulsive Disorder in Women with Multiple Sclerosis (MS): A randomized double-blind controlled trial. Electron Physician. 2016; 8(4): 2243-8.

Khazaeili M, Zargham Hajebi M, Mohamadkhani P, Mirzahoseini H. The Effectiveness of Mindfulness-Based Intervention on Anxiety, Depression and Burden of Caregivers of Multiple Sclerosis Patients Through Web Conferencing. Pract Clin Psychol. 2019; 7(1): 21-32.

Kriakous SA, Elliott KA, Lamers C, Owen R. The Effectiveness of Mindfulness-Based Stress Reduction on the Psychological Functioning of Healthcare Professionals: a Systematic Review. Mindfulness (N Y). 2021; 12(1): 1-28.

Ensan N, Boogar IR, Talepasand S, Estilaee F. The effectiveness of mindfulness-based stress reduction in fatigue severity among patients with multiple sclerosis. Stud Med Sci. 2020; 31(2): 137-45.

Senders A, Hanes D, Bourdette D, Carson K, Marshall LM, Shinto L. Impact of mindfulness-based stress reduction for people with multiple sclerosis at 8 weeks and 12 months: A randomized clinical trial. Mult Scler. 2019; 25(8): 1178-88.

Schmitz N, Hartkamp N, Brinschwitz C, Michalek S, Tress W. Comparison of the standard and the computerized versions of the Symptom Check List (SCL-90-R): a randomized trial. Acta Psychiatr Scand. 2000; 102(2): 147-52.

Ardakani A, Seghatoleslam T, Habil H, Jameei F, Rashid R, Zahirodin A, et al. Construct Validity of Symptom Checklist-90-Revised (SCL-90-R) and General Health Questionnaire-28 (GHQ-28) in Patients with Drug Addiction and Diabetes, and Normal Population. Iran J Public Health. 2016; 45(4): 451-9.

Koh KB, Park JK, Kim CH, Cho S. Development of the stress response inventory and its application in clinical practice. Psychosom Med. 2001; 63(4): 668-78.

Maroufizadeh S, Zareiyan A, Sigari N. Reliability and validity of Persian version of perceived stress scale (PSS-10) in adults with asthma. Arch Iran Med. 2014; 17(5): 361-5.

Maghsoudloo F, Sanagouye MG, Shirazi M. Effectiveness of Cognitive Behavioral Therapy in Reducing Anxiety Thoughts and Life Expectancy in Women with MS. Razi J Med Sci. 2023; 30(1): 206-21. [In Persian].

Cuerda-Ballester M, Bustos A, Sancho-Cantus D, Martínez-Rubio D, Privado J, Alarcón-Jiménez J, et al. Predictive Model of Anxiety and Depression Perception in Multiple Sclerosis Patients: Possible Implications for Clinical Treatment. Bioengineering (Basel). 2024; 11(1): 100.

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Published

2025-04-08

How to Cite

1.
Eftekhari A. The effects of mindfulness-based stress reduction therapy on psychopathology symptoms and stress response in patients with multiple sclerosis: Short communication: Mindfulness-based stress reduction treatment on psychopathology symptoms. Chron Dis J. 2025;13(2).

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Short Communication(s)