SARS-CoV-2-induced myocarditis in pediatric patients: A 10-case series from Sanandaj, Iran: Pediatric myocarditis

Ramyar Rahimi-Darehbagh; Avat Karimi; Shirin Behzadi; Shilan Mohammadi; Behzad Khalafi; Media Babahajiani; Borhan Moradveisi

doi:10.22122/cdj.v12i1.823

Authors

Ramyar Rahimi-Darehbagh Student Research Committee, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran https://orcid.org/0000-0003-4494-4380
Avat Karimi Department of Pediatrics, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran https://orcid.org/0000-0002-9437-8471
Shirin Behzadi Department of Pediatrics, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran https://orcid.org/0000-0001-6191-7021
Shilan Mohammadi Department of Pediatrics, School of Medicine, Be’sat Teaching Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran https://orcid.org/0000-0002-2950-0119
Behzad Khalafi Health Policy Research Center, Health Research Institute, Shiraz University of Medical Sciences, Shiraz AND Virtual School, Tehran University of Medical Sciences, Tehran, Iran https://orcid.org/0000-0001-8913-0415
Media Babahajiani Student Research Committee, Vice Chancellor for Research and Technology, Kurdistan University of Medical Sciences, Sanandaj, Iran https://orcid.org/0000-0002-9308-1879
Borhan Moradveisi Department of Pediatrics, Cancer and Immunology Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran https://orcid.org/0000-0002-1952-4344

DOI:

https://doi.org/10.22122/cdj.v12i1.823

Keywords:

Myocarditis, SARS-CoV-2, Viral Infections, Pediatrics

Abstract

BACKGROUND: Fever, cough, and acute lung involvement are severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) symptoms. Children can be asymptomatic virus carriers and may contribute to the prevalence of coronavirus disease 2019 (COVID-19). Like other viral diseases, the involvement of different heart parts is also seen in this disease. Myocarditis is an inflammation of the myocardium, usually caused by a virus. The primary aim of this study is to investigate the occurrence and clinical manifestations of myocarditis among pediatric patients infected with SARS-CoV-2 in Sanandaj, Iran.

CASE REPORT: In this study, COVID-19 myocarditis cases in Be’sat Hospital, Sanandaj, were documented. Ten pediatric patients with a definitive diagnosis of COVID-19 who were admitted to Be’sat Hospital in Sanandaj in 2020 were included in this study based on clinical trials after seeking echocardiography and confirming myocarditis. The mean age of these 10 study cases was 7.1 years (2 to 13 years). The most common symptoms were fever, respiratory distress, cough, and vomiting. Ceftriaxone, intravenous immunoglobulin (IVIG), and dopamine were the main interventions in these cases. After these cases, all general practitioners and pediatricians in the province and the country were given the necessary warnings. Based on the results, COVID-19 infections, like viral infections, such as enterovirus and adenovirus, are known as the main causes of myocarditis, which appear as local or general myocardial inflammation, tissue necrosis, and ventricular dysfunction.

CONCLUSION: A direct viral attack and overactive immune responses in viral myocarditis can harm heart tissue. Therefore, in COVID-19-infected individuals, serial symptom evaluation and monitoring are necessary.

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SARS-CoV-2-induced myocarditis in pediatric patients: A 10-case series from Sanandaj, Iran

Pediatric myocarditis

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