Restless legs syndrome in lung chemical warfare patients: RLS in chemical warfare patients

Farzaneh Akbari; Fariborz Rezaeitalab; Mohammad Zamiri-Bidary; Fariba Rezaeetalab; Mahnaz Mozdourian; Mohammad Reza Khazdair; Seyyed Mohammad Ata Sharifi-Dalooei; Marzieh Ebrahimi

doi:10.22122/cdj.v10i3.560

Authors

Farzaneh Akbari Department of Internal Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran https://orcid.org/0000-0002-3052-6092
Fariborz Rezaeitalab Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran https://orcid.org/0000-0001-6266-5268
Mohammad Zamiri-Bidary Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran https://orcid.org/0000-0003-1112-794X
Fariba Rezaeetalab Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran https://orcid.org/0000-0003-3836-0944
Mahnaz Mozdourian Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran https://orcid.org/0000-0003-4126-3651
Mohammad Reza Khazdair Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran https://orcid.org/0000-0001-9854-6121
Seyyed Mohammad Ata Sharifi-Dalooei Department of Orthopedics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran https://orcid.org/0000-0003-0329-5409
Marzieh Ebrahimi Lung Diseases Research Center, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran https://orcid.org/0000-0002-6845-5509

DOI:

https://doi.org/10.22122/cdj.v10i3.560

Keywords:

Lung, Chemical Warfare, Chronic Obstructive Pulmonary Disease, Restless Legs Syndrome

Abstract

BACKGROUND: Restless legs syndrome (RLS) has been associated with a variety of diseases, including chronic obstructive pulmonary disease (COPD), which can worsen the symptoms of underlying disease and correlates with co-morbidities. We aimed to investigate RLS in patients with chemical warfare-induced lung diseases.

METHODS: This cross-sectional study recruited patients with sulfur mustard (SM) lung injury, their healthy family members, and patients with COPD from August 2018 to August 2019. COPD was confirmed by medical history, physical examination, and spirometry according to GOLD COPD guidelines. RLS diagnosis was recognized by the International Restless Legs Syndrome Study Group (IRLSSG) and severity was assessed using the International Restless Legs Scale (IRLS) rating scale. Other research measures were COPD Assessment Test (CAT), modified Medical Research Council (mMRC) scale for dyspnoea severity, and Epworth Sleepiness Scale (ESS) for daytime somnolence. Laboratory values included hemoglobin, ferritin, creatinine, and fibrinogen.

RESULTS: This study was conducted on 143 men in three groups: 40 (30.0%) SM-exposed veterans, 73 (55.3%) patients with COPD, and 30 (20.9%) healthy cases. Due to the high prevalence of COPD and better comparison with the control group, more patients with COPD were selected. 20 cases (50%) of the veterans group had RLS, while 25 (32.9%) cases of COPD were affected by this disorder. One normal case (3.33%) suffered from RLS. The chemical veterans who suffered from cough, sputum production, chest pain, and hemoptysis had a higher incidence in proportion to patients with COPD (P < 0.001). The CAT score was significantly higher in SM-exposed veterans with RLS (P = 0.004).

CONCLUSION: RLS is more common in SM lung injuries with higher CAT scores; therefore, evaluation and treatment of RLS are recommended in mustard lung victims.

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Restless legs syndrome in lung chemical warfare patients

RLS in chemical warfare patients

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