Epidemiological and clinical features of human brucellosis
DOI:
https://doi.org/10.22122/cdj.v8i1.498Keywords:
Brucellosis, Human, EpidemiologyAbstract
BACKGROUND: Human brucellosis is an infectious disease and a global issue. Animal sources of brucellosis can contribute to the occurrence of disease in human population. Regarding high incidence of brucellosis in Khaf, Khorasan Razavi Province, Iran, this study aimed to investigate the epidemiological and clinical features of this disease.
METHODS: This was a cross-sectional study. We reviewed all reports in Health Network of Khaf related to patients diagnosed with brucellosis in the period of 2014-2016. We analyzed data using SPSS software and descriptive statistics (frequency and percentages)
RESULTS: Patients’ mean age was 32.00 + 17.23 years, 51.5% of patients were male, 89.5% of them had animal contact, and more than 90.0% of patients had consumed dairy products. According to serological reports, the Wright test showed that the titer of antibody was 1:160 in 35.4% of patients and 1:320 in 27.7% of them. The 2-mercaptoethanol (2ME) test showed that the titer of antibody was 1:80 in 30.0% of patients and 1:160 in 23.8% of them.
CONCLUSION: This study revealed a high incidence of brucellosis among young adults and consumers of unpasteurized dairy products. Therefore, it seems to be necessary to develop preventive strategies and educational programs to reduce the incidence of brucellosis.
References
Al Shehhi N, Aziz F, Al Hosani F, Aden B, Blair I. Human brucellosis in the Emirate of Abu Dhabi, United Arab Emirates, 2010-2015. BMC Infect Dis 2016; 16(1): 558.
Beheshti S, Rezaian GR, Azad F, Faghiri Z, Taheri F. Seroprevalence of brucellosis and risk factors related to high risk occupational groups in Kazeroon, South of Iran. Int J Occup Environ Med 2010; 1(2): 62-8.
Mailles A, Garin-Bastuji B, Lavigne JP, Jay M, Sotto A, Maurin M, et al. Human brucellosis in France in the 21st century: Results from national surveillance 2004-2013. Med Mal Infect 2016; 46(8): 411-8.
Eini P, Keramat F, Hasanzadehhoseinabadi M. Epidemiologic, clinical and laboratory findings of patients with brucellosis in Hamadan, west of Iran. J Res Health Sci 2012; 12(2): 105-8.
Zeinalian Dastjerdi M, Fadaei Nobari R, Ramazanpour J. Epidemiological features of human brucellosis in central Iran, 2006-2011. Public Health 2012; 126(12): 1058-62.
Roushan MR, Amiri MJ. Update on childhood brucellosis. Recent Pat Antiinfect Drug Discov 2013; 8(1): 42-6.
Seleem MN, Boyle SM, Sriranganathan N. Brucellosis: A re-emerging zoonosis. Vet Microbiol 2010; 140(3-4): 392-8.
Aloufi AD, Memish ZA, Assiri AM, McNabb SJ. Trends of reported human cases of brucellosis, Kingdom of Saudi Arabia, 2004-2012. J Epidemiol Glob Health 2016; 6(1): 11-8.
Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global map of human brucellosis. Lancet Infect Dis 2006; 6(2): 91-9.
Pakzad I, Hosseinzadehgan H, Abtahi H, Taherikalani M. Human brucellosis in Iran: Incidence, complication, diagnosis, treatment and prevention. J Pure Appl Microbiol 2013; 7(2): 1177-88.
Cunha BA, Hage JE, Nouri Y. Recurrent fever of unknown origin (FUO): Aseptic meningitis, hepatosplenomegaly, pericarditis and a double quotidian fever due to juvenile rheumatoid arthritis (JRA). Heart Lung 2012; 41(2): 177-80.
Kassiri H, Amani H, Lotfi M. Epidemiological, laboratory, diagnostic and public health aspects of human brucellosis in western Iran. Asian Pac J Trop Biomed 2013; 3(8): 589-94.
Sari I, Altuntas F, Hacioglu S, Kocyigit I, Sevinc A, Sacar S, et al. A multicenter retrospective study defining the clinical and hematological manifestations of brucellosis and pancytopenia in a large series: Hematological malignancies, the unusual cause of pancytopenia in patients with brucellosis. Am J Hematol 2008; 83(4): 334-9.
Moosazadeh M, Nikaeen R, Abedi G, Kheradmand M, Safiri S. Epidemiological and clinical features of people with malta fever in Iran: A systematic review and meta-analysis. Osong Public Health Res Perspect 2016; 7(3): 157-67.
Akhvlediani T, Bautista CT, Garuchava N, Sanodze L, Kokaia N, Malania L, et al. Epidemiological and clinical features of brucellosis in the country of Georgia. PLoS One 2017; 12(1): e0170376.
Minas M, Minas A, Gourgulianis K, Stournara A. Epidemiological and clinical aspects of human brucellosis in Central Greece. Jpn J Infect Dis 2007; 60(6): 362-6.
Sofian M, Aghakhani A, Velayati AA, Banifazl M, Eslamifar A, Ramezani A. Risk factors for human brucellosis in Iran: A case-control study. Int J Infect Dis 2008; 12(2): 157-61.
Gur A, Geyik MF, Dikici B, Nas K, Cevik R, Sarac J, et al. Complications of brucellosis in different age groups: A study of 283 cases in southeastern Anatolia of Turkey. Yonsei Med J 2003; 44(1): 33-44.
Moradi G, Hobad H, Majidpour MS, Ghaderi A. Epidemiological status survey of 3880 case of brucellosis in Kurdistan. Iranian Journal of Infectious Diseases and Tropical Medicine 2006; 11(33): 27-33. [In Persian].
Olsen SC, Palmer MV. Advancement of knowledge
of Brucella over the past 50 years. Vet Pathol 2014; 51(6): 1076-89.
Lytras T, Danis K, Dounias G. Incidence patterns and occupational risk factors of human brucellosis in Greece, 2004-2015. Int J Occup Environ Med 2016; 7(4): 221-6.
Farahani S, Shahmohamadi S, Navidi I, Sofian S. An investigation of the epidemiology of brucellosis in Arak City, Iran, (2001-2010). J Arak Univ Med Sci 2012; 14(Suppl 3): 49-54. [In Persian].
Diju IU. Brucellosis--an under-estimated cause of arthralgia & muscular pains in general population. J Ayub Med Coll Abbottabad 2009; 21(2): 128-31.
Buzgan T, Karahocagil MK, Irmak H, Baran AI, Karsen H, Evirgen O, et al. Clinical manifestations and complications in 1028 cases of brucellosis: A retrospective evaluation and review of the literature. Int J Infect Dis 2010; 14(6): e469-e478.
