Chronic urticaria associated with malignancies: A review article

Zeinab Nazari, Javad Ghaffari, Negar Ghaffari

DOI: 10.22122/cdj.v7i2.385


BACKGROUND: Chronic urticaria is a cutaneous disorder defined by the presence of hives and flare for over six weeks. Etiology of chronic urticaria is not clear in 80 to 90 percent of patients. Malignancies are possible associations with allergic disorders such as urticaria. The purpose of this article was to review the expression of chronic urticaria with various malignancies.

METHODS: We searched in PubMed, Scopus, and EMBASE databases in English using the keywords chronic urticaria, urticarial, malignancy, and cancer. Inclusion criteria were both full and brief articles, case reports, case series, and original article up to June 2018.

RESULTS: We found 258 articles on the primary search. After screening by two researchers, 23 articles were included. Most studies failed to find a link between hives and malignancy. Four studies showed a relationship between hives and malignancy. Five studies showed no relationship between hives and malignancy, and suggested that urticaria could even have a protective effect. As there were no homogenous results, we could not write a meta-analytic study.

CONCLUSION: The relationship between chronic urticaria and malignancy is not clear. We need a more organized researches to clarify the association between urticaria and malignancies.


Urticaria; Neoplasm; Skin; Association

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Ghaffari J, Farid Hossaini R, Rafatpanah H, Jabbari Azad F, Shahmohammadi S. Chronic urticaria in children: Etiologies, clinical manifestations, diagnosis and treatment. J Pediatr Rev 2013; 1(2): 55-68.

Lee N, Lee JD, Lee HY, Kang DR, Ye YM. Epidemiology of Chronic Urticaria in Korea Using the Korean Health Insurance Database, 2010-2014. Allergy Asthma Immunol Res 2017; 9(5): 438-45.

Stallings AP, Dreskin SC, Franks MM, Sicherer SH. Urticarial (Hives) and angioedema. In: Kliegman RM, Stanton BM, Geme J, Schor NF, Editors. Nelson textbook of pediatrics. Philadelphia, PA: Elsevier Health Sciences; 2015. p. 1126-30.

Kulthanan K, Jiamton S, Thumpimukvatana N, Pinkaew S. Chronic idiopathic urticaria: Prevalence and clinical course. J Dermatol 2007; 34(5): 294-301.

Mehrinejad SA, Jalili M, Ghaffari J. Comparison between psychological traits of patients with various atopic allergic diseases and healthy volunteers: A case-control study. Indian J AllergyAsthma Immunol 2013; 27(1): 42-6.

Tedeschi A, Girolomoni G, Asero R. AAITO Position paper. Chronic urticaria: Diagnostic workup and treatment. Eur Ann Allergy Clin Immunol 2007; 39(7): 225-31.

Ghaffari J, Shahmohammadi S, Ashrafi H, Ranjbar AR, Ghaffari N. Omalizumab (Xolair) in children above 12 years with chronic urticaria: A review of literature. J Pediatr Rev 2015; 3(1): e152.

Chen YJ, Wu CY, Shen JL, Chen TT, Chang YT. Cancer risk in patients with chronic urticaria: A population-based cohort study. Arch Dermatol 2012; 148(1): 103-8.

McWhorter WP. Allergy and risk of cancer. A prospective study using NHANESI followup data. Cancer 1988; 62(2): 451-5.

Karakelides M, Monson KL, Volcheck GW, Weiler CR. Monoclonal gammopathies and malignancies in patients with chronic urticaria. Int J Dermatol 2006; 45(9): 1032-8.

Greiner D, Schofer H, Boehncke WH. Urticaria associated with a small cell carcinoma of the lung. Cutis 2002; 69(1): 49-50.

Wang H, Diepgen TL. Is atopy a protective or a risk factor for cancer? A review of epidemiological studies. Allergy 2005; 60(9): 1098-111.

Vena JE, Bona JR, Byers TE, Middleton E Jr, Swanson MK, Graham S. Allergy-related diseases and cancer: an inverse association. Am J Epidemiol 1985; 122(1): 66-74.

Linabery AM, Jurek AM, Duval S, Ross JA. The association between atopy and childhood/adolescent leukemia: a meta-analysis. Am J Epidemiol 2010; 171(7): 749-64.

Severson RK, Davis S, Thomas DB, Stevens RG, Heuser L, Sever LE. Acute myelocytic leukemia and prior allergies. J Clin Epidemiol 1989; 42(10): 995-1001.

Wen W, Shu XO, Linet MS, Neglia JP, Potter JD, Trigg ME, et al. Allergic disorders and the risk of childhood acute lymphoblastic leukemia (United States). Cancer Causes Control 2000; 11(4): 303-7.

De P, Abbasi R, Senadhira T, Orr P, Ullah A. Urticaria and large cell undifferentiated carcinoma of lung. Dermatol Online J 2005; 11(3): 45.

Lindelof B, Sigurgeirsson B, Wahlgren CF, Eklund G. Chronic urticaria and cancer: An epidemiological study of 1155 patients. Br J Dermatol 1990; 123(4): 453-6.

Krishnan KR, Ownby DR. A solitary mastocytoma presenting with urticaria and angioedema in a 14-year-old boy. Allergy Asthma Proc 2010; 31(6): 520-3.

Eriksson NE, Mikoczy Z, Hagmar L. Cancer incidence in 13811 patients skin tested for allergy. J Investig Allergol Clin Immunol 2005; 15(3): 161-6.

Eriksson NE, Holmen A, Hogstedt B, Mikoczy Z, Hagmar L. A prospective study of cancer incidence in a cohort examined for allergy. Allergy 1995; 50(9): 718-22.

Merrill RM, Isakson RT, Beck RE. The association between allergies and cancer: what is currently known? Ann Allergy Asthma Immunol 2007; 99(2): 102-16.

Campanelli A, Prins C, Saurat JH. Chronic urticaria revealing a colonic adenocarcinoma. J Am Acad Dermatol 2005; 52(6): 1105.

Manganoni AM, Tucci G, Venturini M, Farisoglio C, Baronchelli C, Calzavara Pinton PG. Chronic urticaria associated with thyroid carcinoma: Report of 4 cases. J Investig Allergol Clin Immunol 2007; 17(3): 192-5.

Baroni A, Faccenda F, Russo T, Piccolo V. Figurate paraneoplastic urticaria and prostate cancer. Ann Dermatol 2012; 24(3): 366-7.

Hu HH, Ying KJ, Wu XH, Chai Y. Urticaria as the initial presentation of early stage bronchioloalveolar carcinoma: A case report. Chin Med J (Engl) 2012; 125(11): 2065-6.

Murota H, Shoda Y, Ishibashi T, Sugahara H, Matsumura I, Katayama I. Improvement of recurrent urticaria in a patient with Schnitzler syndrome associated with B-cell lymphoma with combination rituximab and radiotherapy. J Am Acad Dermatol 2009; 61(6): 1070-5.

Shamsadini S, Varesvazirian M, Shamsadini A. Urticaria and lip fasciculation may be prodromal signs of brain malignancy. Dermatol Online J 2006; 12(3): 23.

Zhang Y, Morita E, Matsuo H, Ueda D, Dekio S. Urticarial erythema associated with IgA myeloma. J Dermatol 2004; 31(8): 661-5.

Clore LS Jr, Stafford CT. Chronic urticaria as a presenting sign of hairy cell leukemia. Allergy Asthma Proc 1999; 20(1): 51-5.

O'Donnell E, Havyer R. Breast malignancy masquerading under the cloak of acute urticaria. BMJ Case Rep 2014; 2014.

Larenas-Linnemann D, Saini SS, Azamar-Jacome AA, Maurer M. Chronic urticaria can be caused by cancer and resolves with its cure. Allergy 2018; 73(7): 1562-6.


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