Brucellosis Presenting as a Localized Fluid Collection in the Leg: A Case Report from an Endemic Area
Brucellosis Presenting as Leg Abscess
Keywords:
Brucellosis, Body Fluids, Zoonosis, LegAbstract
Introducton:Brucellosis is one of the most important zoonotic diseases worldwide, and Kurdistan is an endemic province in Iran. Microorganisms can be found in different fluids and tissues of the body. This study is the first to report the detection of Brucella in an isolated collection.
Case Report: The patient was a 53-year-old Iranian farmer whose chief complaint was weight loss, malaise, low back pain, and pitting edema in his left leg. He had no history of underlying disease, and his Wright test was positive. As an incidental finding during color Doppler sonography performed to rule out DVT, a localized fluid collection was observed in the medial and distal portions of the left leg. Fluid was aspirated, and the results showed a positive Coombs Wright test and a positive PCR test for brucellosis. The patient's brucellosis was successfully treated with a combination regimen of Doxycycline (100mg PO BID), Rifampin (600mg PO daily), and Gentamycin (80mg/2ml IV TDS), and supportive care. After a 3-week hospitalization, symptoms resolved, and the patient showed significant improvement, including weight gain, at the 2-month follow-up.
Conclusion: This is an uncommon case of Brucella infection in a localized fluid collection in an endemic area. Brucellosis can be found in fluid collections that may have no connection to any body fluids.
References
Elbehiry A, Aldubaib M, Marzouk E, Abalkhail A, Almuzaini AM, Rawway M, et al. The development of diagnostic and vaccine strategies for early detection and control of human brucellosis, particularly in endemic areas. Vaccine. 2023;11(3):654.
Rubach MP, Halliday JE, Cleaveland S, Crump JA. Brucellosis in low-income and middle-income countries. Curr Opin Infect Dis. 2013;26(5):404.
Aghamohammad S, Rastin M, Mostafavi E, Anaraki AH, Rahravani M, Sadaf RA, Moravedji M, Rohani M. Determination of seroprevalence of brucellosis in livestock and high-risk populations in Kurdistan, Western Iran. Comp Immunol Microbiol Infect Dis. 2023;93:101942.
Bahmani N, Bahmani A. A review of brucellosis in the Middle East and control of animal brucellosis in an Iranian experience. Rev Res Med Microbio. 2022 Jan 1;33(1):e63-9.
Shi C, Wang L, Lv D, Wang G, Mengist HM, Jin T, Wang B, Huang Y, Li Y, Xu Y. Epidemiological, clinical and laboratory characteristics of patients with brucella infection in Anhui Province, China. Infect Drug Resist. 2021:2741-52.
Tuon FF, Gondolfo RB, Cerchiari N. Human‐to‐human transmission of Brucella–a systematic review. Trop Med Int Health. 2017;22(5):539-46.
Yagupsky P, Morata P, Colmenero JD. Laboratory diagnosis of human brucellosis. Clin Microbiol Rev. 2019; 33.
Wang FS, Shahzad K, Zhang WG, Li J, Tian K. Atypical presentation of shoulder brucellosis misdiagnosed as subacromial bursitis: A case report. World J Clin Cases. 2021;9(4):927.
Salehi M, Farbod F, Khalili H, Rahmani H, Jafari S, Abbasi A. Comparing efficacy and safety of high-dose and standard-dose rifampicin in the treatment of brucellosis: a randomized clinical trial. J Antimicrob Chemother. 2023;78(4):1084-91.
Olfatifar M, Hosseini SM, Shokri P, Khodakarim S, Khadembashi N, Pordanjani SR. How to improve the human brucellosis surveillance system in Kurdistan Province, Iran: reduce the delay in the diagnosis time. Epidemiol Health. 2020;42.
Altunçekiç Yildirim A, Kurt C, Çetinkol Y. Brucellosis with rare complications and review of diagnostic tests: A Case Report. J Med Case Rep. 2022;16(1):492.
Wang J, Zhang Q. Early diagnosis and treatment of acute brucellosis knee arthritis complicated by acute osteomyelitis: Two Cases Report. BMC Infect Dis. 2022;22(1):430.
Abuzinadah AR, Milyani HA, Alshareef A, Bamaga AK, Alshehri A, Kurdi ME. Brucellosis causing subacute motor polyradiculopathy and the pathological correlation of pseudomyopathic electromyography: A Case Report. Clin Neurophysiol Pract. 2020;5:130-4.
Ledbetter LN, Salzman KL, Sanders RK, Shah LM. Spinal neuroarthropathy: pathophysiology, clinical and imaging features, and differential diagnosis. Radiographics. 2016;36(3):783-99.
Abeer DH, Tasneem A, Razan S, Usra G, Rabee A. Breast abscess secondary to brucellosis: A Rare Case Report. J. Investig Med High Impact Case Rep. 2025; 13:23247096251347405.
Sunnetcioglu M, Ceylan MR, Atmaca M, Baran Aİ, Mentes O, Ücler R. Rare brucellosis involvement: Thyroid gland abscess. East J Med. 2015;20(1):62.
Kazaz I, Yazici E, Aygar İS, Hoşbul T. A Case of thyroid gland abscess caused by brucella melitensis. Mikrobiyol Bul. 2024 Apr 1;58(2):217-23.
Rizkalla JM, Alhreish K, Syed IY. Spinal brucellosis: a case report and review of the literature. J Orthop Case Rep. 2021 Mar;11(3):1.
Oliveira SC. Host immune responses and pathogenesis to Brucella spp. infection. J pathog. 2021;10(3):288.
Vitry MA, Hanot Mambres D, Deghelt M, Hack K, Machelart A, Lhomme F, Vanderwinden JM, Vermeersch M, De Trez C, Pérez-Morga D, Letesson JJ. Brucella melitensis invades murine erythrocytes during infection. Infect immun. 2014;82(9):3927-38.
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